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-In humans, smoking and specific chemical exposures in the workplace increase the risk of bladder cancer. However, many cases of human bladder cancer cannot be explained by these exposures.
-A case-control study of household dogs* was conducted to determine if exposure to topical insecticides was associated with the occurrence of bladder cancer. Information by telephone interview was obtained from owners of 89 dogs with bladder cancer and 71 age- and breed size-matched control dogs with other chronic diseases. Bladder cancer risk was found to be unrelated to exposure to sidestream cigarette smoke and chemicals used in the home. However, bladder cancer risk was significantly increased by topical insecticide use on the dog.
*Glickman, LT et al. Epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs. J Toxicol & Environ Health, 28:407-414, 1989.